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NFL Week 10 Upset Predictions: Giants, Steelers, and Eagles Eye Wins

NFL Week 10 Upset Predictions: Giants, Steelers, and Eagles Eye Wins
Editorial
  • PublishedNovember 6, 2025

As the 2025 NFL season reaches its mid-point, analysts from Sports Illustrated have identified several potential upsets for Week 10. With favorites dominating the season, underdogs have emerged as intriguing options for bettors. Among the highlighted matchups, the New England Patriots are set to face the Tampa Bay Buccaneers, while the Pittsburgh Steelers look to continue their winning streak against the Los Angeles Chargers.

Patriots Seek Victory Against Buccaneers

The Patriots will embark on a challenging journey to Tampa Bay, where they will take on the Buccaneers on October 5, 2025. Coming off a much-needed bye week, the Buccaneers, led by Baker Mayfield, are expected to return rejuvenated. New England’s offensive line will be crucial as it attempts to protect quarterback Drake Maye against the Buccaneers’ aggressive defense. Currently, the Patriots are riding a six-game winning streak, making them a team to watch in this matchup.

Steelers Aim to Maintain Lead in AFC North

The Steelers, having recently defeated the Indianapolis Colts 27-17, are set to face a weakened Chargers team lacking star tackles Joe Alt and Rashawn Slater. Mike Tomlin’s squad boasts strong defensive players, including T.J. Watt, who could exploit a struggling offensive line. Despite the Steelers’ defense ranking low in several categories, they have the potential to put pressure on the Chargers and secure another victory.

Giants vs. Bears: A Close Call

In a matchup that could swing either way, the Chicago Bears will host the New York Giants. Both teams have faced challenges this season, with the Bears holding an average scoring margin of just -1.5. Using advanced metrics like DVOA, the Giants and Bears rank closely at 22nd and 23rd, respectively. Jaxson Dart, the Giants’ quarterback, has shown promise, ranking 16th in Expected Points Added plus Completion Percentage Over Expected, contrasting with the performance of the Bears’ Williams, who ranks 23rd. This game is anticipated to be a tight contest.

Eagles Look to Impress Against Packers

The Philadelphia Eagles will host the Green Bay Packers in another highly anticipated matchup. Despite some inconsistencies, the Eagles currently lead the NFC and aim to maintain their momentum after a bye week. With key players like Saquon Barkley and A.J. Brown expected to return to full health, Philadelphia seeks to capitalize on their offensive strengths. The Packers have recently suffered significant defeats, raising doubts about their ability to perform under pressure.

As the NFL Week 10 unfolds, these matchups promise excitement and the potential for surprises. Bettors and fans alike will be eager to see if the underdogs can rise to the occasion, making for a thrilling week in professional football.

For those interested in the betting landscape, it is essential to stay informed as odds may change leading up to game time. If you or someone you know is struggling with gambling, support is available through organizations such as 1-800-GAMBLER.

Editorial
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Editorial

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